Levetiracetam-induced seizure aggravation associated with continuous spikes and waves during slow sleep in children with refractory epilepsies.
نویسندگان
چکیده
We present a patient with cryptogenic focal epilepsy and another with Dravet syndrome, who experienced seizure aggravation and negative myoclonus, associated with continuous spikes and waves during slow sleep, induced by levetiracetam. For both patients levetiracetam was discontinued, and there was significant improvement of this particular electroclinical picture.
منابع مشابه
A prospective open-labeled trial with levetiracetam in pediatric epilepsy syndromes: Continuous spikes and waves during sleep is definitely a target
Although LVT is currently extensively prescribed in childhood epilepsy, its effect on the panel of refractory epilepsy syndromes has not been entirely evaluated prospectively. In order to study the efficacy and safety of LVT as adjunctive therapy according to syndromes, we included 102 patients with refractory seizures (6 months to 15 years) in a prospective open-labeled trial. The responder ra...
متن کاملA prospective study of levetiracetam efficacy in epileptic syndromes with continuous spikes-waves during slow sleep
PURPOSE To evaluate the add-on effect of levetiracetam (LEV) treatment on the EEG and clinical status of children with continuous spikes-waves during slow sleep (CSWS). METHODS 20 children with CSWS refractory to other conventional antiepileptic drugs (AEDs) received LEV 45-50 mg/kg/day as add-on treatment, and were prospectively followed for a minimum period of 18 months. The patient populat...
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PURPOSE In epilepsy with continuous spikes and waves during slow sleep (CSWS), which is a representative epileptic syndrome of secondary bilateral synchrony (SBS), the urgent suppression of this electroencephalographic (EEG) abnormality may be necessary to prevent the progression of neuropsychological impairments. The purpose of this study was to determine the efficacy of levetiracetam (LEV) on...
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Some antiepileptic drugs (AEDs) have been reported to aggravate generalized seizures. We have seen three children whose myoclonic seizures increased on starting treatment with Levetiracetam. In all seizures aggravation was temporally associated to the introduction of the drug. All became seizure-free on withdrawal of levetiracetam with a switch to an alternative antiepileptic drug and this pers...
متن کاملFrontal Lobe Growth Retardation and Dysfunctions in Children with Epilepsy: A 3-D MRI Volumetric Study
Behavioral abnormalities have been noted in specific epilepsy syndromes involving the frontal lobe. Epilepsies that involve the frontal lobe, such as frontal lobe epilepsy (FLE), atypical evolution of benign childhood epilepsy with centrotemporal spikes (BCECTS), and epilepsy with continuous spike-waves during slow sleep (CSWS), are characterized by impairment of neuropsychological abilities, f...
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عنوان ژورنال:
- Epileptic disorders : international epilepsy journal with videotape
دوره 12 2 شماره
صفحات -
تاریخ انتشار 2010